Ajit Kulkarni,Manish Bhatia's Design of Regioselective Bilayer Floating Tablets of PDF

By Ajit Kulkarni,Manish Bhatia

ISBN-10: 3656855552

ISBN-13: 9783656855552

learn Paper (postgraduate) from the 12 months 2014 within the topic Pharmicology, grade: 2, , language: English, summary: the aim of the learn used to be to layout bilayer floating drugs of Propranolol hydrochloride and Lovastatin to provide speedy unlock of Lovastatin and regulated liberate of Propranolol hydrochloride. Bilayer floating pills made out of layers, quick unencumber layer and regulated unencumber layer. Direct compression procedure used to be hired for formula of the bilayer pills. brief time period sped up balance stories have been conducted at the ready pills. all of the formulations floated for greater than 12h. greater than ninety% Lovastatin was once published inside 30 min. from the formulations. HPMC K4M and Xanthan gum retarded the discharge of Propranolol hydrochloride from the managed liberate layer for 12h. After balance experiences, obvious degradation of either the medication have been stumbled on however the drug content material was once chanced on to be in the variety. Diffusion exponent (n) was firm for the entire formulations (0.53-7). in accordance with coefficient of correlation(R), the discharge of Propranolol hydrochloride was once stumbled on to persist with combined free up trend of Hixson-Crowell, Korsmeyer-Peppas and matrix, other than formula F6 and F9, which 0 order liberate development. Statistical research published that there has been no major distinction in in vitro unlock trend of the medication sooner than and after balance studies.

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Design of Regioselective Bilayer Floating Tablets of Propranolol Hydrochloride and Lovastatin for Biphasic Release Profile by Ajit Kulkarni,Manish Bhatia


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