By Rodrick Wallace,Deborah Wallace
This booklet, in keeping with released stories, takes a distinct point of view at the 30-year cave in of pharmaceutical productiveness within the look for small molecule “magic bullet” interventions. The relentless escalation of inflation-adjusted expense in line with authorized medication within the usa — from $200 million in 1950 to $1.2 billion in 2010 — has pushed giants to, at most sensible, slavish imitation in drug layout, and at worst, abandonment of analysis and embracing of common fraud in purchaser marketing.
The e-book adapts formalism throughout a few disciplines to the tactic for layout of mutilevel interventions, focusing first on molecular, mobile, and bigger scale examples, after which extending the argument to the simplifications supplied by means of the dominant function of social and cultural constructions and methods in person and inhabitants styles of wellbeing and fitness and illness.
In position of “magic bullets”, we needs to now observe “magic suggestions” that act throughout either the dimensions and point of association. This ebook offers an introductory roadmap to the recent instruments that may be wanted for the layout of such strategies.
- Beyond Magic Bullets
- Expanding the Theory
- Dynamic ‘Regression Models’
- An Evolutionary Excursion
- Example: psychological Disorders
- Example: Protein Folding
- Example: Glycome Determinants
- Example: Glycan/Lectin common sense Gates
- Example: IDP common sense Gates
- History and Health
- Beyond Glasperlenspiel
- Mathematical Appendix
Readership: Undergraduate, graduate, researchers and pros in biomathematics, biostatistics, mathematical modeling, complicated platforms and pharmaceuticals.
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Extra info for A Mathematical Approach to Multilevel, Multiscale Health Interventions:Pharmaceutical Industry Decline and Policy Response
A Mathematical Approach to Multilevel, Multiscale Health Interventions:Pharmaceutical Industry Decline and Policy Response by Rodrick Wallace,Deborah Wallace